Have you ever launched a Flex app into a production environment only to find out that it doesn't work?! You probably wanted run the debugger right then and there to trace the problem. Here's how using Flex Builder 3.
Step 1 Overwrite the version on the server with the debug version usually found in your bin-debug folder while developing.
Step 2 In Flex builder go to the top menu and select Project -> Properties
Step 3 Go to "Run/Debug" Settings
Step 4 Your app should be listed under Launch Configuratoins, select it and press "Edit"
Step 5 Uncheck the "use defaults" button in the lower portion and then in the first field called "debug" type the URL of your app on the server
Step 6 Hit Apply, and then go ahead and debug! You're good to go!
Obviously once you've solved the problem you'll want to export a release build to place on the server as it will be much smaller.