Here's a link to my presentation, http://goo.gl/WTlj9. Source code will be posted here shortly. Or you can search to see some outdated code from DrupalCon SF and DesignCamp Boston.
I wrote this Adobe Air app to generate CSS sprites for myself. It's pretty simple to run, but keep in mind that it's the first build and probably NOT STABLE yet.
One problem I've always had is developing websites that look exactly the same in all browsers. I'm usually able to get Safari & Firefox perfect and nearly so with IE7+. I've learned a number of things over the years and I'm going to put them in this post. I'll probably update it a few times as things evolve and we move towards CSS3.
CSS Consistency
Start your CSS by setting all your padding and margins to 0!